JOURNALS PUBLISHING AND PEER REVIEW

PubMed vs PubMed Central vs MEDLINE

Guide · 1 min read · Last updated 2026-10-31

PubMed is a free search engine for biomedical citations; MEDLINE is NLM's curated subset of journal articles indexed with MeSH; PubMed Central (PMC) is a free full-text archive of biomedical and life-sciences articles. They overlap but serve different purposes. For the narrower comparison of PubMed and MEDLINE, see PubMed vs MEDLINE.

Comparison

FeaturePubMedMEDLINEPubMed Central
What it isSearch system for citations and abstractsIndexed database of selected journalsArchive of free full text
ContentMEDLINE plus other citationsRecords indexed with MeSHFull-text articles (many open access)
Full text?Mostly links outNo, citationsYes
Indexing with MeSH?Only for MEDLINE recordsYesNot necessarily
Inclusion criteriaVarious, including PMC contentNLM journal selection processDeposit by journals, funders or authors, with policies

What this means

  • Searching: search PubMed for citations; remember that not all records have MeSH terms.
  • Full text: use PMC or the free full text filter to find open-access versions.
  • Citing: cite the article (with DOI), not the database. PMID and PMCID are identifiers of records in PubMed and PMC respectively.
  • Publishing: being in PMC does not mean that a journal is in MEDLINE, and vice versa.

Illustrative example

Invented for teaching. A funder-mandated manuscript is deposited in PMC and appears in PubMed with a PMCID but is not MEDLINE-indexed, because the journal was not selected for MEDLINE. A search using only MeSH terms would miss it.

Common pitfalls

  • Using the terms interchangeably.
  • Assuming that appearing in PubMed signals journal quality.

Key takeaways

  • PubMed = search; MEDLINE = curated subset; PMC = free full-text archive.
  • Describe your sources accurately.

References and further reading

  1. National Library of Medicine. MEDLINE, PubMed, and PMC (PubMed Central): how are they different? Link
  2. National Library of Medicine. MEDLINE overview. Link
  3. National Library of Medicine. PubMed Central (PMC): about. Link
  4. National Library of Medicine. PubMed User Guide. Link

Related reading

This page is general educational information about research methods. It is not medical, legal or regulatory advice; follow your institution's ethics board and your target journal's instructions.