RESEARCH IDEAS AND PICO

How to Know Whether Your Research Idea Is Original

Guide · 1 min read · Last updated 2026-10-31

To check originality, run a systematic search for your exact question in literature databases, trial and review registries, and preprint servers, record what you find, and then decide whether your study adds something new, replicates responsibly, or should be changed.

Where to look

  • PubMed/MEDLINE with MeSH and free-text terms (see How to Search PubMed Effectively).
  • Trial registries such as ClinicalTrials.gov for ongoing and unpublished trials.
  • PROSPERO for registered systematic reviews.
  • Preprint servers such as medRxiv for recent unpublished work.
  • Conference abstracts in your specialty.

What counts as "new enough"

  • A new question or population.
  • A better design or larger sample than previous studies.
  • A new setting where results may differ.
  • A replication that is clearly labelled and justified, since replication has value when earlier results are uncertain.

Illustrative example

Invented for teaching. A student's idea is a review of intermittent fasting and blood pressure. A search finds three recent systematic reviews. She reads them and finds none include studies of adults over 65, and all pool short trials. She revises the question to focus on older adults and longer follow-up, or decides to do a different project.

Keep a short log: date, database, exact search string, number of results, and the three most relevant papers with one line on how your question differs. This log protects you from repeating the search later, helps your supervisor judge novelty, and can be reused in a protocol or in the background section of a manuscript. If you are planning a systematic review, also check whether a protocol or review is already registered.

Common pitfalls

  • A one-keyword search that misses relevant studies.
  • Ignoring registries and preprints.
  • Treating "someone has studied it" as meaning the question is closed.

Key takeaways

  • Search broadly and document the search.
  • Originality can come from population, design, setting or replication.
  • If your idea exists, adapt it rather than duplicate it.

References and further reading

  1. National Library of Medicine. PubMed User Guide. Link
  2. National Library of Medicine. Medical Subject Headings (MeSH). Link
  3. ClinicalTrials.gov (U.S. National Library of Medicine). Link
  4. PROSPERO: International prospective register of systematic reviews (Centre for Reviews and Dissemination, University of York). Link

Related reading

This page is general educational information about research methods. It is not medical, legal or regulatory advice; follow your institution's ethics board and your target journal's instructions.